Physiological proteomics of gram-positive bacteria

Comunicaciones a congreso

Tuning the scattering length with an optically induced Feshbach resonance

We demonstrate optical tuning of the scattering length in a Bose-Einstein condensate as predicted by Fedichev {\em et al.} [Phys. Rev. Lett. {\bf 77}, 2913 (1996)]. In our experiment atoms in a $^{87}$Rb condensate are exposed to laser light which is tuned close to the transition frequency to an excited molecular state. By controlling the power and detuning of the laser beam we can change the atomic scattering length over a wide range. In view of laser-driven atomic losses we use Bragg spectroscopy as a fast method to measure the scattering length of the atoms.Comment: submitted to PRL, 5 pages, 5 figure

Magnetic field control of elastic scattering in a cold gas of fermionic lithium atoms

We study elastic collisions in an optically trapped spin mixture of fermionic lithium atoms in the presence of magnetic fields up to 1.5kG by measuring evaporative loss. Our experiments confirm the expected magnetic tunability of the scattering length by showing the main features of elastic scattering according to recent calculations. We measure the zero crossing of the scattering length that is associated with a predicted Feshbach resonance at 530(3)G. Beyond the resonance we observe the expected large cross section in the triplet scattering regime

Phonon-induced rotation of the electronic nematic director in superconducting Bi2_{2}Se3_{3}

The doped topological insulator $A_{x}\mathrm{Bi_{2}Se_{3}}$, with $A=\{\mathrm{Cu},\mathrm{Sr},\mathrm{Nb}\}$, becomes a nematic superconductor below $T_{c}\sim3-4\,\mathrm{K}$. The associated electronic nematic director is described by an angle $\alpha$ and is experimentally manifested in the elliptical shape of the in-plane critical magnetic field $H_{c2}$. Because of the threefold rotational symmetry of the lattice, $\alpha$ is expected to align with one of three high-symmetry directions corresponding to the in-plane nearest-neighbor bonds, consistent with a $Z_{3}$-Potts nematic transition. Here, we show that the nematic coupling to the acoustic phonons, which makes the nematic correlation length tend to diverge along certain directions only, can fundamentally alter this phenomenology in trigonal lattices. Compared to hexagonal lattices, the former possesses a sixth independent elastic constant $c_{14}$ due to the fact that the in-plane shear strain doublet $(\epsilon_{xx}-\epsilon_{yy},-2\epsilon_{xy})$ and the out-of-plane shear strain doublet $(2\epsilon_{yz},-2\epsilon_{xz})$ transform as the same irreducible representation. We find that, when $c_{14}$ overcomes a threshold value, which is expected to be the case in doped $\mathrm{Bi_{2}Se_{3}}$, the nematic director $\alpha$ unlocks from the high-symmetry directions due to the competition between the quadratic phonon-mediated interaction and the cubic nematic anharmonicity. This implies the breaking of the residual in-plane twofold rotational symmetry ($C_{2x}$), resulting in a triclinic phase. We discuss the implications of these findings to the structure of nematic domains and to the shape of the in-plane $H_{c2}$ in $A_{x}\mathrm{Bi_{2}Se_{3}}$, and to presence of nodes inside the superconducting state.Comment: 24 pages, 10 figure

Observation of the Pairing Gap in a Strongly Interacting Fermi Gas

We study fermionic pairing in an ultracold two-component gas of $^6$Li atoms by observing an energy gap in the radio-frequency excitation spectra. With control of the two-body interactions via a Feshbach resonance we demonstrate the dependence of the pairing gap on coupling strength, temperature, and Fermi energy. The appearance of an energy gap with moderate evaporative cooling suggests that our full evaporation brings the strongly interacting system deep into a superfluid state.Comment: 18 pages, 3 figure

SNAI transcription factors mediate epithelial--mesenchymal transition in lung fibrosis

Background: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterised by accumulation of activated (myo)fibroblasts and excessive extracellular matrix deposition. The enhanced accumulation of (myo)fibroblasts may be attributed, in part, to the process of transforming growth factor \textgreekb1 (TGF\textgreekb1)-induced epithelial--mesenchymal transition (EMT), the phenotypic switching of epithelial to fibroblast-like cells. Although alveolar epithelial type II (ATII) cells have been shown to undergo EMT, the precise mediators and mechanisms remain to be resolved. The objective of this study is to investigate the role of SNAI transcription factors in the process of EMT and in IPF.Methods: Using quantitative reverse transcription-PCR (RT-PCR), immunofluorescence, immunohistochemistry, western blotting, as well as gain- and loss-of-function studies and functional assays, the role of SNAI1 and SNAI2 in TGF\textgreekb1-induced EMT in ATII cells in vitro was assessed; and the expression of SNAI transcription factors was analysed in experimental and human IPF in vivo.Results: TGF\textgreekb1 treatment increased the expression and nuclear accumulation of SNAI1 and SNAI2, in concert with induction of EMT in ATII cells. SNAI overexpression was sufficient to induce EMT, and small interfering RNA (siRNA)-mediated SNAI depletion attenuated TGF\textgreekb1-induced ATII cell migration and EMT. SNAI expression was elevated in experimental and human IPF and localised to hyperplastic ATII cells in vivo.Conclusions: The results demonstrate that TGF\textgreekb1-induced EMT in ATII cells is essentially controlled by the expression and nuclear translocation of SNAI transcription factors. Increased SNAI1 and SNAI2 expression in experimental and human IPF in vivo suggests that SNAI-mediated EMT may contribute to the fibroblast pool in idiopathic pulmonary fibrosis

Dynamics of a strongly interacting Fermi gas: the radial quadrupole mode

We report on measurements of an elementary surface mode in an ultracold, strongly interacting Fermi gas of 6Li atoms. The radial quadrupole mode allows us to probe hydrodynamic behavior in the BEC-BCS crossover without being influenced by changes in the equation of state. We examine frequency and damping of this mode, along with its expansion dynamics. In the unitarity limit and on the BEC side of the resonance, the observed frequencies agree with standard hydrodynamic theory. However, on the BCS side of the crossover, a striking down shift of the oscillation frequency is observed in the hydrodynamic regime as a precursor to an abrupt transition to collisionless behavior; this indicates coupling of the oscillation to fermionic pairs.Comment: 11 pages, 11 figures v2: minor change

Exploring the BEC-BCS Crossover with an Ultracold Gas of 6^6Li Atoms

We present an overview of our recent measurements on the crossover from a Bose-Einstein condensate of molecules to a Bardeen-Cooper-Schrieffer superfluid. The experiments are performed on a two-component spin-mixture of $^6$Li atoms, where a Fesh\-bach resonance serves as the experimental key to tune the s-wave scattering length and thus to explore the various interaction regimes. In the BEC-BCS crossover, we have characterized the interaction energy by measuring the size of the trapped gas, we have studied collective excitation modes, and we have observed the pairing gap. Our observations provide strong evidence for superfluidity in the strongly interacting Fermi gas.Comment: Proceedings of ICAP-2004 (Rio de Janeiro). Review on Innsbruck BEC-BCS crossover experiments with updated Feshbach resonance positio